Transmembrane Protease TMPRSS11B Promotes

Updegraff et al show that transmembrane protease TMPRSS11B is upregulated in lung squamous cell carcinoma where it interacts with MCT4 and its obligate chaperone Basigin TMPRSS11B catalytic activity promotes Basigin solubilization which enhances lactate export and glycolytic metabolism thereby promoting tumorigenesis

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α

The pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB) is associated with the accumulation of aggregated forms of the α-synuclein (αSN) protein An early event in the neuropathology of PD and DLB is the loss of synapses and a corresponding reduction in the level of synaptic proteins However the molecular mechanisms involved in synapse

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BB

aminoethyl) benzenesulfonyl fluoride and 25 mg/1 of aprotinin pepstatin and leupeptin using six strokes in a Potter-Elvehjem type homogenizer All extractions were carried out on ice The homogenates were cen- trifuged at 100000xg for 30 min at 4C using a Beckman L8-M ultracentrifuge (Palo Alto CA) The

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Intake of Sucrose

FIGURE 1 Intake of sucrose-sweetened water induces insulin resistance in APP/PS1 mice A mice with free access to sucrose (10%)-sweetened water (sucrose) gained significantly more body weight than mice drinking water with no added sucrose (control) after 5 weeks B intraperitoneal glucose tolerance response Blood glucose content was monitored over time following an intraperitoneal injection

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Reactive Oxygen Species Regulate the Levels of Dual

Dual Oxidases (DUOX) 1 and 2 are efficiently expressed in thyroid gut lung and immune system The function and the regulation of these enzymes in mammals are still largely unknown We report here that DUOX 1 and 2 are expressed in human neuroblastoma SK-N-BE cells as well as in a human oligodendrocyte cell line (MO3-13) and in rat brain and they are induced by platelet

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TNF

Despite new developments in cancer therapy chemotherapy and radiotherapy remain the cornerstone of breast cancer treatment Therefore finding ways to reduce the toxicity and increase sensitivity is particularly important Tumor necrosis factor alpha (TNF-α) exerts multiple functions in cell proliferation differentiation and apoptosis In the present study we

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Aspergillus fumigatus Activates

Aspergillus fumigatus is one of the most frequent causes of invasive mycoses in immunosuppressed individuals [1 2] More profound knowledge of the pathogenesis of aspergillosis and the interactions between A fumigatus and immune cells might help to develop new therapeutic approaches Emerging evidence assigns a crucial role to thrombocytes as

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Dicer up

Dicer is a ribonuclease III enzyme in biosynthesis of miRNAs regulators of gene expression involved in macrophage differentiation We found a specific truncation of Dicer in monocytic cells resulting from apparently constitutive cleavage by a serine protease Inhibition of this proteolytic truncation which occurred during macrophage differentiation in presence of TLR ligands or

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The effects of exercise and ambient temperature on dietary

Therefore the purpose of this study was to investigate the effects of arduous physical activity in varying ambient temperatures on dietary intake appetite sensation and appetite-regulating hormone concentrations in military personnel throughout an eight hour day

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The neurotrophic compound J147 reverses cognitive

Despite years of research there are no disease-modifying drugs for Alzheimer's disease (AD) a fatal age-related neurodegenerative disorder Screening for potential therapeutics in rodent models of AD has generally relied on testing compounds before pathology is present thereby modeling disease prevention rather than disease modification

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American Journal of Respiratory Cell and Molecular

Mice exposed to O2 die after 3 or 4 d with diffuse alveolar damage and alveolar edema Extensive cell death is evident by electron microscopy in the alveolar septa affecting both endothelial and epithelial cells The damaged cells show features of both apoptosis (condensation and margination of chromatin) and necrosis (disruption of the plasma membrane)

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SAFETY DATA SHEET 4

Product name 4-(difluoromethoxy)benzenesulfonyl Chloride Product number FD105883 CAS number 351003-34-4 1 2 Relevant identified uses of the substance or mixture and uses advised against Identified uses Laboratory reagent Manufacture of substances Research and development 1 3 Details of the supplier of the safety data sheet Supplier Carbosynth Ltd 89

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[Full text] Treatment Of Magnesium

The dissected tissues were well distributed in ice-cold Tris-HCl buffer with 25 mM which included protease inhibitors (benzenesulfonyl fluoride bestatin leupeptin and aprotinin) and 2 mM EDTA The homogenate was centrifuged with 11 kg for 5 mins at 4C the pellet was resuspended in fresh buffer (sodium dodecyl sulfate Tris h

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1999 Fluoride Abstracts Part 1 Fluoride Action Network

Fluoride content of lung tissue homogenate was significantly higher in groups A and B (mean 1 206 ppm and 1 978 ppm respectively) as compared to control (0 1585 ppm) It was concluded that prolonged fluoride ingestion damages pulmonary tissues of rabbits

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Cooperative D1 Degradation in the

Light energy constantly damages photosynthetic apparatuses ultimately causing impaired growth Particularly the sessile nature of higher plants has allowed chloroplasts to develop unique mechanisms to alleviate the irreversible inactivation of photosynthesis Photosystem II (PSII) is known as a primary target of photodamage Photosynthetic organisms have evolved the so

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Portal pressure responses and angiotensin peptide

After 1 wk of acclimatization the rats were anesthetized with an intraperitoneal injection of ketamine-xylazine mixture (75 and 5 mg/kg body wt respectively Therapon Victoria Australia) and given a single dose of carprofen (5 mg/kg Lyppard Victoria Victoria Australia) subcutaneously prior to surgery to limit postoperative discomfort

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Thiazolidenediones Mediate Apoptosis in Prostate Cancer

Certain members of the thiazolidenedione family of the peroxisome proliferator-activated receptor γ (PPARγ) agonists such as troglitazone and ciglitazone exhibit antitumor effects however the underlying mechanism remains inconclusive This study shows that the effect of these thiazolidenedione members on apoptosis in prostate cancer cells is independent of PPARγ activation

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SAFETY DATA SHEET 3 5

3 5-Bis(trifluoromethyl)benzenesulfonyl chloride Hazardous combustion products Thermal decomposition or combustion products may include the following substances: Oxides of carbon Oxides of sulphur Hydrogen fluoride (HF) Hydrogen chloride (HCl) 5 3 Advice for firefighters Special protective equipment for firefighters

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Benzylidene Lactam Compound KNK437 a

Cells exposed to heat or other types of stressors transiently synthesize a group of proteins known as heat shock proteins (HSPs) A nonlethal heat treatment can elicit in the cells an ability to resist subsequent lethal heat treatments We report here that a novel benzylidene lactam compound KNK437 dose-dependently inhibited the acquisition of thermotolerance and the induction of

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FAP

Gelatinase activity is inhibited by serine-protease inhibitors such as phenylmethylsulfonyl fluoride (PMSF) 4-(2-aminoethyl)-benzenesulfonyl fluoride hydrochloride (AEBSF) 4-amidino phenylsulfonyl fluoride (APSF) and diisopropyl fluorophosphate (DFP) N-ethylmaleimide (NEM) and phenylmethylsulfonyl fluoride (PMSF)

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Angiotensin II evokes sensory long

Losartan apocynin and 4-(2-aminoethyl)benzenesulfonyl fluoride prevented ANG II-induced sLTF which was absent in mice deficient in gp91 phox the catalytic subunit of the Nox2 complex These results demonstrate that repetitive application of ANG II induces sLTF of the carotid body via activation of Nox2 by AT 1 receptors

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A novel Alzheimer's disease drug candidate targeting

2017-07-14CAD-31 is an Alzheimer's disease (AD) drug candidate that was selected on the basis of its ability to stimulate the replication of human embryonic stem cell-derived neural precursor cells as well as in APPswe/PS1ΔE9 AD mice To move CAD-31 toward the clinic experiments were undertaken to determine its neuroprotective and pharmacological properties

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Interrelationship Between Cardiac Hypertrophy Heart

From the Department of Medicine Division of Nephrology McMaster University and St Joseph's Healthcare Hamilton Ontario Canada Cardiac hypertrophy is typically regarded as a compensatory mechanism of the heart in response to increased systemic demand for cardiac output The development of

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Analytical Enzyme Chymotrypsin

Physical Properties Molecular Weight: 25 kDa 1 (Bovine) pI: 8 752 (Bovine) Extinction coefficient: E1%= 20 4 (280nm) Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor chymotrypsinogen α-Chymotrypsin is the predominant form of active enzyme produced from it's zymogen Chymotrypsinogen A

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Dominant negative effects by inactive Spa47 mutants

Type three secretion systems (T3SS) are complex nano-machines that evolved to inject bacterial effector proteins directly into the cytoplasm of eukaryotic cells Many high-priority human pathogens rely on one or more T3SSs to cause disease and evade host immune responses underscoring the need to better understand the mechanisms through which T3SSs function

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Ego3 a regulator of TORC1 signaling is degraded by the

Ego3 a regulator of TORC1 signaling is degraded by the intralumenal fragment pathway Qiao Jin Target of rapamycin complex 1 (TORC1) is a conserved protein kinase complex whose activity controls metabolism in eukaryotic cells To function TORC1 and its regulators are localized to lysosome membranes The mechanism(s) that control TOR complex

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Appetite

2016-05-11Body composition in early life influences development of obesity during childhood and beyond Appetite-regulating hormones (ARH) play a role in regulation of food intake and might thus influence body composition in later life Studies on associations between ARH and body composition in early life are limited In 197 healthy term infants we measured serum

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Chronic Treatment With 5

Recent studies have demonstrated that chronic administration of AICAR (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) an activator of the AMP-activated protein kinase increases hexokinase activity and the contents of total GLUT4 and glycogen in rat skeletal muscles To explore whether AICAR also affects insulin-stimulated glucose transport and GLUT4 cell

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The Use of Oxytocin to Improve Feeding and Social Skills

BACKGROUND AND OBJECTIVES: Patients with Prader–Willi syndrome (PWS) display poor feeding and social skills as infants and fewer hypothalamic oxytocin (OXT)-producing neurons were documented in adults Animal data demonstrated that early treatment with OXT restores sucking after birth Our aim is to reproduce these data in infants with PWS

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